Research suggests that stressful or traumatic experiences can be associated with changes in the epigenome, the dynamic system of chemical modifications that helps regulate gene activity without changing the DNA sequence. Experimental studies in animals and plants demonstrate that some environmentally influenced epigenetic changes can persist across generations. Studies of Holocaust survivors and their children, as well as families affected by war and displacement, have reported suggestive differences in stress-related biological markers. However, human findings remain limited and sometimes difficult to separate from shared environments, caregiving, and other influences. They do not yet establish that trauma-induced epigenetic changes are reliably inherited across multiple human generations. The epigenome is responsive to experience, which is relevant both to adaptation and to the possibility of change.